Combustion-derived nanoparticles: mechanisms of pulmonary toxicity.

Adverse Health Effects from Combustion-Derived Nanoparticles: The Relative Role of Intrinsic Particle Toxicity and Host Response

Interactions of nanoparticles with pulmonary structures and cellular responses.

Combustion-derived and synthetic nano-sized particles (NSP) have gained considerable interest among pulmonary researchers and clinicians for two main reasons. 1) Inhalation exposure to combustion-derived NSP was associated with increased pulmonary and cardiovascular morbidity and mortality as suggested by epidemiological studies. Experimental evidence has provided a mechanistic picture of the a...

Invited Review Interactions of nanoparticles with pulmonary structures and cellular responses

Mühlfeld C, Rothen-Rutishauser B, Blank F, Vanhecke D, Ochs M, Gehr P. Interactions of nanoparticles with pulmonary structures and cellular responses. Am J Physiol Lung Cell Mol Physiol 294: L817–L829, 2008. First published February 8, 2008; doi:10.1152/ajplung.00442.2007.—Combustion-derived and synthetic nano-sized particles (NSP) have gained considerable interest among pulmonary researchers a...

Deducing in Vivo Toxicity of Combustion-Derived Nanoparticles from a Cell-Free Oxidative Potency Assay and Metabolic Activation of Organic Compounds

BACKGROUND The inhalation of combustion-derived nanoparticles (CDNPs) is believed to cause an oxidative stress response, which in turn may lead to pulmonary or even systemic inflammation. OBJECTIVE AND METHODS In this study we assessed whether the in vivo inflammatory response--which is generally referred to as particle toxicity-of mice to CDNPs can be predicted in vitro by a cell-free ascorb...

Nanoparticles, human health hazard and regulation.

New developments in technology usually entail some hazard as well as advantage to a society. Hazard of a material translates into risk by exposure of humans and/or their environment to the agent in question, and risk is reduced by control of exposure, usually guided by regulation based on understanding of the mechanisms of harm. We illustrate risks relating to the causation of diseases associat...